WORKSHOP

The Ubiquitin Workshop 2010

Date: August 23, 2010
Location: Four Seasons Hotel, Philadelphia, PA
Summary of Workshop

The workshop is designed to familiarize researchers and executives with state of the art technology and methods being used to decipher the complex ubiquitin signaling networks. The workshop will cover the available tools and reagents currently used to understand ubiquitin mediated signaling. In 2009 the workshop focused on HTS assays using surrogate substrates. In 2010 the workshop will focus on tools aimed at uncovering the physiological function of ubiquitin conjugating and deconjugating enzymes. These sessions will also include extensive discussion sessions to allow attendees to share their own experiences and ask advice on how to approach problems. Space is limited to ensure that all attendees have the opportunity to interact with experts in the ubiquitin field.

Pre-Conference Workshop Program:

Session 1:
Session Chair: Dr. James E. Strickler

1:00pm Session Introduction

Dr. Paul W. Sheppard
ENZO Life Sciences(UK) LTD

1:10pm Tools for Characterizing Polyubiquitin Linkages

Dr. Donald S. Kirkpatrick
Genentech, Inc.

1:50pm Characterization of Proteasome Complexes

Using Proteomic Approaches

Dr. Lan Huang

University of California, Irvine School of Medicine

2:30pm Role of Ubiquitination and UBPY-dependent deubiquitination in the

endocytosis and lysosomal targeting of plasma membrane KCa3.1

Dr. Corine Balut

University of Pittsburgh, School of Medicine

2:50pm New approaches for determining the

activity of deubiquitinylating enzymes

Dr. James E. Strickler
LifeSensors, Inc.

3:30pm Selected Talk from Abstract (deubiquitinylase related)

TBA

3:50pm Break

Session 2:

Session Chair: Dr. Paul W. Sheppard

4:20pm E3 Ligases and the Challenges of

Drug Discovery: Lessons From the

Mechanism of the Trim Ligase
Superfamily

        Dr. Arthur L. Haas
        LSU Health Sciences Center
        School of Medicine

5:00pm An Emerging Therapeutic Target Class - Where to Start?

The Development of a High Throughput Homogeneous Assay

to Identify Inhibitors of Ubiquitin Ligases

Dr. Paul Andrews

Amgen, Inc.

5:30pm A genome-wide screen for modulators

of cell death induced by the NEDD8-

activating enzyme inhibitor MLN4924

Dr. Eric S. Lightcap
Millennium: The Takeda Oncology Company

6:00pm Selected Talk from Abstract

6:30pm UbiScan: Quantifying Ubiquitination Sites in Cells and Tissues

Matthew Stokes, Ph.D
Cell Signaling Technology, Inc.

7:00pm Event Ends

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